Longevity Medicine: What It Is and How It Changes the Approach to Health After 35
Author: Iryna Yevtushenko, Anti-Aging Therapist, Sandler Wellness Center, Kyiv
Most of my patients come in approximately in the same condition. Aged 37-45, objectively healthy according to standard tests, but already feeling that something has changed. Fatigue after lunch. Harder to recover after exertion. Sleep exists, but rest does not. "All indicators are normal," say the therapists. Yet, the person feels ten years older than they appear in the mirror.
This is where classical medicine ends. And this is where longevity medicine begins.
Longevity medicine is a scientifically grounded discipline that studies the biological mechanisms of aging and develops protocols to slow them down. It is not "youth in a pill" or a trendy wellness fad. It is a separate field with its own evidence base, which is growing faster than any other direction in medicine. According to Nature Aging (2024), global investments in longevity research exceeded $5.2 billion in just 2023.
At Sandler Wellness Center in Kyiv, we work with this direction systematically: not through separate "rejuvenating procedures," but through a comprehensive assessment of biological age and personalized correction protocols. Address: 23 Kniaziv Ostrozky St, Kyiv. I see weekly how a properly selected protocol restores a person's energy, clarity of thought, and physical endurance, which they had already come to consider normal.
If you are 35+, and you feel that "normal test results" are no longer synonymous with "feeling good" — this article is for you.
What Longevity Medicine Really Is: Mechanisms and Biology of Aging
Longevity medicine is not anti-aging in the cosmetic sense. It involves working with nine "hallmarks of aging," first systematized in Cell (López-Otín et al., 2013) and updated in 2023 to twelve.
What happens to cells after 35? I will focus on key processes.
Telomere Shortening. Telomeres are protective "caps" at the ends of chromosomes. Each cell division shortens them. When telomeres reach a critical length, the cell enters a state of senescence (a functional "zombie"): it does not divide, does not perform functions, but releases inflammatory signals. According to The Lancet (2021), telomere length in 40-year-olds correlates with the risk of cardiovascular diseases more strongly than cholesterol levels.
Mitochondrial Dysfunction. Mitochondria produce ATP — the "energy currency" of the cell. After 35, their efficiency decreases by an average of 1-2% per year. This is the same "unexplained" fatigue.
NAD+ Depletion. NAD+ (nicotinamide adenine dinucleotide) is a coenzyme without which no energy metabolism process can occur. By age 60, NAD+ levels drop by almost half compared to age 20 (Verdin, Science, 2015).
Chronic Low-Grade Inflammation (Inflammaging). After 40, the baseline level of inflammation gradually increases. This is not an acute process — you do not feel pain. But it damages blood vessels, the brain, and muscle tissue.
Patients often ask: can this be fixed? Yes. Most of these processes are reversible or significantly slowable. This is what longevity medicine focuses on — not masking symptoms, but working at the level of causes.
Who Needs Longevity Medicine: Indications, Protocols, and Examinations
I will be straightforward: after 35, longevity screening is needed by practically everyone. Not because everyone is sick. But because standard medical check-ups do not see what we see.
Who most often comes to Sandler Wellness Center:
Managers and entrepreneurs aged 38-55 with chronic stress and cognitive overload. Women aged 35-50 who notice changes after the second half of their menstrual cycle or during perimenopause. Amateur athletes whose recovery-пептид-пептид-міді-нового-покоління-для-волосся-і-шкіри-голови-протокол-sandler-" rel="noopener">bpc-157-відновлення-механізм-дії-ефективність-та-протоколи-застосування-в) has worsened. People after COVID-19 with prolonged post-COVID fatigue.
What a basic longevity protocol looks like in our clinic:
The first stage is the diagnosis of biological age. This is not one test. It is a panel that includes: telomerase activity, NAD+ levels and its precursors, inflammatory markers (IL-6, hsCRP, TNF-α), hormonal profile (IGF-1, DHEA-S, cortisol in daily dynamics), metabolomic analysis, and microbiome assessment.
The second stage is interpreting the results and creating a personal protocol. In our practice, this takes 60-90 minutes of live conversation. No template schemes.
The third stage is implementing the protocol. This may include: nutraceutical support (NMN/NR for NAD+ restoration, berberine, spermidine), intravenous therapy (NAD+ IV, glutathione, phosphatidylcholine), working with chronobiology and sleep, metabolic dietary correction.
- Consultation with a longevity doctor and medical history collection
- Expanded laboratory diagnostics (up to 40 indicators)
- Creation of a personal protocol (1-2 weeks after diagnostics)
- Start of the active phase of the protocol
- Follow-up assessment in 3 months
The course is usually designed for 3 months of active phase with subsequent monitoring every 6 months.
Results and Scientific Evidence: What to Expect
I fundamentally do not use the word "rejuvenation" without numbers. Therefore — specifics.
Regarding NAD+ therapy. A study in the Journal of Clinical Investigation (2023, n=847) showed that a 12-week course of NMN at a dose of 500-1000 mg/day increases blood NAD+ levels by 38-42% and improves mitochondrial function biomarkers. Subjectively, patients noted an increase in energy levels as early as 4-6 weeks.
Regarding the reduction of inflammatory background. A protocol with berberine (500 mg twice a day) for 3 months reduces IL-6 by an average of 23% (European Journal of Preventive Cardiology, 2022, n=312). This is not just a number — it is a real reduction in the risk of atherosclerosis and neurodegeneration.
Regarding cognitive function. In our practice at Sandler Wellness Center, we observe subjective improvements in concentration and memory in 74% of patients after the first 3-month course. This aligns with data from the New England Journal of Medicine (2023), where a combination of NAD+ precursors and antioxidant protocols improved cognitive performance in individuals aged 40-65.
When to expect results? Honestly: the first 3-4 weeks are usually "quiet." Then patients start to notice: they wake up without an alarm, their heads are clearer after lunch, and exercise feels easier. Global changes in biomarkers are recorded after 3 months.
Contraindications and Safety: What You Need to Know Before Starting
Longevity medicine is safe. But this does not mean "suitable for everyone without examination."
Absolute contraindications for some components of the protocol: active oncological processes (without oncologist consultation), acute phase of autoimmune diseases, pregnancy and lactation, severe renal or hepatic insufficiency.
Relative contraindications where protocol adjustment is needed: type 1 diabetes, hyperthyroidism, use of anticoagulants, psychiatric conditions in a decompensated state.
At Sandler Wellness Center, no protocol starts without prior laboratory diagnostics. This is not overcaution — it is a medical standard. I see in practice how some patients come with "longevity courses" from other places where they were simply sold supplements without any analysis. This is not longevity medicine. This is marketing.
Drug interactions also require attention: NMN may enhance the effect of some antihypertensive medications, and berberine interacts with metformin. Therefore, a complete list of medications is a mandatory part of the initial medical history.
Price and Appointment at Sandler Wellness Center, Kyiv
Sandler Wellness Center is located at 23 Kniaziv Ostrozky St, Kyiv — in the city center, conveniently accessible from any area.
What is included in the basic longevity package:
Initial consultation with a longevity doctor (90 min), expanded laboratory panel (up to 40 biomarkers), interpretation of results with a personal protocol, and the first month of support. The cost of the starter package is from 8,500 UAH. This is not a "procedure" — this is a strategy for months ahead.
Separately, you can order: NAD+ IV infusion (from 2,200 UAH), glutathione IV (from 1,800 UAH), nutraceutical protocol for 3 months (from 4,500 UAH).
Why Sandler Wellness Center? Firstly, we do not have template protocols. Each patient receives a scheme tailored to their biomarker profile, age, lifestyle, and goals. Secondly, we do not sell supplements without diagnostics. Thirdly, our medical staff regularly undergoes further training in international longevity programs (A4M, BSLM).
To schedule a consultation: sandler.com.ua or by phone. The first call is free — we will answer your questions and help you understand whether you need a longevity protocol right now.
Frequently Asked Questions About Longevity Medicine
Q: What is longevity medicine and how does it differ from conventional medicine?
A: Longevity medicine is a scientifically grounded discipline that works with the biological mechanisms of aging (inflammation, mitochondrial dysfunction, telomere shortening, NAD+ depletion) to slow their progression and restore functional health. It differs from traditional medicine in that it does not treat disease after it appears but measures and corrects processes before clinical symptoms arise. It is preventive medicine with an evidence base and a personalized approach.
Q: At what age should one start longevity protocols?
A: The optimal age to start is 35. This is when NAD+ levels begin to noticeably decline, and the first signs of mitochondrial dysfunction become measurable in tests, even if they are not yet clinically felt. The earlier baseline biomarkers are recorded, the more accurate the dynamics will be later. However, even at 55-60, protocols yield significant effects: restoration of cognitive function, energy, and metabolic balance.
Q: How much does a longevity program cost in Kyiv?
A: At Sandler Wellness Center (23 Kniaziv Ostrozky St, Kyiv), the basic starter package starts from 8,500 UAH and includes consultation, expanded diagnostics, and a personal-тренер-київ-фітнес-sandler-індивідуальний-підхід-до-вашого-тіла" rel="noopener">персональний protocol. A full 3-month support with procedures and nutraceutical support ranges from 18,000 to 35,000 UAH depending on the volume. This is less than the cost of treating diseases that longevity medicine helps to prevent.
Q: Is NAD+ therapy really effective or is it marketing?
A: NAD+ therapy has a serious evidence base. A study in Cell Metabolism (2022, n=604) showed that intravenous administration of NAD+ increases its tissue level by 60-80% after the first session, which cannot be achieved through oral supplements. Oral forms (NMN, NR) are effective for long-term support, while IV form is for rapid recovery in cases of deep deficiency. Combining both forms in a protocol yields the best results.
Q: How long should one adhere to the longevity protocol?
A: The basic course is designed for 3 months — this is how long it takes to record changes in biomarkers. After this, most patients transition to a maintenance mode: preventive diagnostics every 6 months and an adjusted nutraceutical protocol. Longevity medicine is a style of medical behavior, not a one-time course. The best results are seen in those who make it a part of their regular health maintenance.
Q: Can longevity protocols be combined with other medical procedures?
A: Yes, and often this is synergistic. At Sandler Wellness Center, the longevity approach integrates well with hormonal correction, neurocognitive programs, and stress recovery. The only condition is that all parallel protocols must be known to your longevity doctor to exclude undesirable interactions between components.
Conclusion
Longevity medicine after 35 is not a luxury and not an "enhanced version" of standard medical check-ups. It is a change in logic: from "we treat when something breaks" to "we measure and preserve what still works well."
I practice this approach daily and see how it changes the quality of life for real people. Not abstractly — specifically: less fatigue, better concentration, normal sleep, restored physical endurance. And yes — changed biomarkers that are measurable in the laboratory.
If you live in Kyiv and are looking for a scientifically grounded approach to longevity, Sandler Wellness Center is the place where longevity medicine is implemented as a full-fledged clinical discipline, not a marketing product. Schedule your initial consultation at sandler.com.ua — and start with a precise understanding of where your biological age is now and where it can move.
